The observed insufficient a significant accumulation of PHN in brain subsequent the intraventricular administration of (+)-amphetamine as well as the formation of appreciable amounts of PHN from (+)-POH in brain tissue in vivo supports the see which the aromatic hydroxylation of amphetamine following its systemic administration happens predominantly within the periphery, and that POH is then transported through the blood-Mind barrier, taken up by noradrenergic neurones in brain where (+)-POH is transformed in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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